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C 6
Mutations in cartilage extracellular matrix proteins and their effects on tissue integrity and function


Funding period 01. Jan. 2008 - 31. Dec. 2010

Frank Zaucke Mats Paulsson
Institute for Biochemistry II Institute for Biochemistry II
  CECAD Cologne
   
Publications Publications
   

Selected publications

Year 2009

Blumbach, K., Bastiaansen-Jenniskens, Y.M., DeGroot, J., Paulsson, M., Van Osch, G.J.V.M., and Zaucke, F. (2009) Combined role of collagen IX and COMP in cartilage matrix assembly – COMP counteracts collagen IX limitation of cartilage collagen fibril growth. Arthritis and Rheumatism 60, 3676-3685.

Buchstein, N., Hoffmann, D., Smola, H., Lang, S., Paulsson, M., Niemann, C., Krieg, T., and Eming, S.A. (2009). Alternative Proteolytic Processing of Hepatocyte Growth Factor during Wound Repair. American Journal of Pathology 174, 2116-2128.

Ehlen, H.W.A., Sengle, G., Klatt, A.R., Talke, A., Muller, S., Paulsson, M., and Wagener, R. (2009). Proteolytic Processing Causes Extensive Heterogeneity of Tissue Matrilin Forms. Journal of Biological Chemistry 284, 21545-21556.

Gebauer, J.M., Keene, D.R., Olsen, B.R., Sorokin, L.M., Paulsson, M., and Wagener, R. (2009) Mouse AMACO, a kidney and skin basement membrane associated molecule that mediates RGD-dependent cell attachment. Matrix Biology 28, 456-462.

Klatt, A.R., Klinger, G., Paul-Klausch, B., Kühn, G., Renno, J.H., Wagener, R., Paulsson, M., Schmidt, J., Malchau, G., and Wielckens, K. (2009) Matrilin-3 activates the expression of osteoarthritis-associated genes in primary human chondrocytes. FEBS Letters 583, 3611-3617.

Malan, D., Reppel, M., Dobrowolski, R., Roell, W., Smyth, N., Hescheler, J., Paulsson, M., Bloch, W., and Fleischmann, B.K. (2009). Lack of Laminin gamma 1 in Embryonic Stem Cell-Derived Cardiomyocytes Causes Inhomogeneous Electrical Spreading Despite Intact Differentiation and Function. Stem Cells 27, 88-99.

Spohn, G., Kleinridders, A., Wunderlich, F.T., Watzka, M., Zaucke, F., Blumbach, K., Geisen, C., Seifried, E., Muller, C., Paulsson, M., Bruning, J.C., and Oldenburg, J. (2009). VKORC1 deficiency in mice causes early postnatal lethality due to severe bleeding. Thromb Haemostasis 101, 1044-1050
1230.

Wagener, R., Gara, S.K., Kobbe, B., Paulsson, M., and Zaucke, F. (2009). The knee osteoarthritis susceptibility locus DVWA on chromosome 3p24.3 is the 5 ' part of the split COL6A4 gene. Matrix Biology 28, 307-310.

Zaucke, F., and Grassel, S. (2009). Genetic mouse models for the functional analysis of the perifibrillar components collagen IX, COMP and matrilin-3: Implications for growth cartilage differentiation and endochondral ossification. Histol Histopathol 24, 1067-1079.



Year 2008

Blumbach, K., Niehoff, A., Paulsson, M., and Zaucke, F. (2008). Ablation of collagen IX and COMP disrupts epiphyseal cartilage architecture. Matrix Biology 27, 306-318.

Schmitz, M., Niehoff, A., Miosge, N., Smyth, N., Paulsson, M., and Zaucke, F. (2008). Transgenic mice expressing D469Delta mutated cartilage oligomeric matrix protein (COMP) show growth plate abnormalities and sternal malformations. Matrix Biology 27, 67-85.

Gara, S.K., Grumati, P., Urciuolo, A., Bonaldo, P., Kobbe, B., Koch, M., Paulsson, M., and Wagener, R. (2008). Three novel collagen VI chains with high homology to the alpha 3 chain. Journal of Biological Chemistry 283, 10658-10670.

Gebauer, J.M., Murller, S., Hanisch, F.G., Paulsson, M., and Wagener, R. (2008). O-glucosylation and O-fucosylation occur together in close proximity on the first epidermal growth factor repeat of AMACO (VWA2 protein). Journal of Biological Chemistry 283, 17846-17854.

Grimm-Gunter, E.M.S., Milbrandt, M., Merkl, B., Paulsson, M., and Plomann, M. (2008). PACSIN proteins bind tubulin and promote microtubule assembly. Experimental Cell Research 314, 1991-2003.

Kalkhof, S., Haehn, S., Ihling, C., Paulsson, M., Smyth, N., and Sinz, A. (2008). Determination of disulfide bond patterns in laminin beta 1 chain N-terminal domains by nano-high-performance liquid chromatography/matrix-assisted laser desorption/ionization time-of-flight/time-of-flight mass spectrometry. Rapid Commun Mass Sp 22, 1933-1940.

Maier, S., Paulsson, M., and Hartmann, U. (2008). The widely expressed extracellular matrix protein SMOC-2 promotes keratinocyte attachment and migration. Experimental Cell Research 314, 2477-2487.


CMMC-Research Building
Grand Opening


Medfacilities GmbH

Winter Term 2009/2010
Current lecture
Molecular Medicine
Overview about topics


This lecture for postgraduate students of the Medical Faculty and the Faculty of Math. and Natural Sciences as well as interested students is offered within the Postgraduate Programme Molecular Medicine.  

March 19, 2010
Genomics Day 2010
Cologne Center for Genomics


April 17 - 20, 2010
SAWC & WHS 2010
The Symposium on Advanced Wound Care and the Wound Healing Society in Orlando, Florida


May 26. - 29, 2010
5th European Molecular Imaging Meeting - EMIM 2010

(Warsaw, Poland)

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